On the day that Lou James finds her father dead on the garage floor, she leaves her small hometown and heads for Toronto on a Greyhound, initiating a series of events that will reshape her life. Lou moves in with her brother and begins a new existence all the while trying to make sense of her father's unexpected death and the sudden loss of her place in the world.

Amidst the strangeness of life in Toronto, where vibrancy and violence mix, Lou builds a small community: Isabelle, the welcoming neighbour and new best friend; Sal, Lou's angry but big-hearted godfather; despairing Donnie, a troubled fledgling drug dealer; dreamy Finn, lead singer in a post-punk band, and mysterious Stella, the old woman who spends her days seated on the back steps of a locked church door surrounded by plastic bags and bottles of Pepsi. When a series of savage and homicidal acts plague her new neighbourhood, Lou, following in her journalist father's footsteps, attempts to investigate.

As her final year of high school unfolds, Lou comes perilously close to discovering the truth, and violence erupts, once again unravelling her world. She hops on a Greyhound, destination unknown, propelled by the urgent need to bridge the distance between the life she shared with her father and this precarious new existence where he grows ever more remote to her.